Discovery of novel small molecule activators of β-catenin signaling.

HeLa 57A cells expressing human TLR2/6 (A) and control cells transfected with vector without insert (B) were stimulated with wild type, D lgt , D lgt ::pGA14- cm , and D lgt

To find out whether the relatively low endogenous levels of Mdm2 could also have influence on CMV promoter activity, we com- pared luciferase activity in U2OS cells transfected with

HeLa cells were left untreated (Medium, A) or transiently transfected with control RNAi (B) or CK18 RNAi (C).. After 24 h, cells were infected with tis- sue culture trypomastigotes

When PTPRZ1-250- transfected HEK293T cells were co-transfected with HIF-2a in the presence of ELK1 siRNA, luciferase reporter activity decreased more than 75% as compared to

To explore whether S100A6 promotes PDAC cell migration and invasion via regulation of β - catenin, we transfected stable β -catenin-knockdown Panc-1 cells with a S100A6

(B) HIF-1 a cooperated with Osx to inhibit Wnt pathway activity. HEK293 cells were transfected with a Topflash reporter along with 25 ng b - catenin without or with different groups

HEK293T cells were transfected with indicated expression plasmids of RIG-I wild type, mutations and ubiquitin, Novel E3/Stimulator of RIG-I... facilitated the ubiquitination of

pBDP activity was examined in MCF7 and U2OS cells co-transfected with the pBDP construct and either an E2F1 WT, an E2F1 trans-activation domain deletion mutant (ΔTA), or an