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Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells.

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Academic year: 2017

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Table 1. Comparison of SK4 expression in tumor subtypes for 50 patients using Fisher’s exact test.
Fig 3A and 3B). However, for T47D cells, the OD values of the 20-μM TRAM-34 and control group were not apparently different, with values of 0.57 ± 0.01 and 0.56 ± 0.01, respectively (p>0.05; Fig 3C)
Fig 3. Blockage of SK4 channels inhibits MDA-MB-231 cell proliferation and colony formation ability, but not that of T47D cells
Fig 4. Blockage of SK4 channels promotes apoptosis in MDA-MB-231 cells but not T47D cells
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