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Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock.

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Academic year: 2017

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Fig. 1. KDM3A is phosphorylated at S264 by MSK1 under HS conditions. KDM3A phosphorylation was determined via co-IP and western blot assays of Jurkat cells that were treated with heat shock at 42 u C (HS) for 0–60 min
Fig. 4. p-KDM3A is recruited by Stat1 to elicit chromatin remodeling of a Stat1 target gene
Fig. 5. MSK1 is a prerequisite for Stat1 target gene activation via KDM3A phosphorylation

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