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Lin28 mediates radiation resistance of breast cancer cells via regulation of caspase, H2A.X and Let-7 signaling.

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Academic year: 2017

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Figure 1. Lin28 expression is associated with sensitivity to radiation in breast cancer cells
Figure 2. Lin28 knockdown by siRNA increases sensitivity to radiation. T47D cells with naturally high Lin28 expression were transfected with Lin28 siRNA and then were treated with radiation at the indicated doses
Figure 3. The SK-BR-3 cell line with stable Lin28 expression is relatively tolerant of radiation treatment
Figure 5. Lin28 inhibits expression of c-H2AX and p21. (A). The expression of Lin28, HER2, H2A.X, c-H2A.X and p21 in SK-BR-3 and S1 cells was determined 4 days after treatment of radiotherapy by Western blotting

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