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Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.

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Academic year: 2017

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Fig 1. Blocking αIIbβ3-fibrinogen interactions prevents spreading of human platelets and thrombus formation over immobilized IgG
Fig 2. αIIbβ3-deficient platelets fail to spread, form thrombi, or efficiently secrete granule contents over immobilized IgG
Fig 3. Role of Src- and Syk-family kinases in platelet activation by immobilized IgG. (A) Washed human platelets were incubated in IgG-coated microtiter chamber slides in the presence of DMSO (Control), PP3, PP2, or PRT318 for 30 minutes
Table 1. Mass spectrometry analysis of FcγRIIa cytoplasmic domain phosphopeptides generated from in vitro kinase reactions.
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