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A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.

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Academic year: 2017

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Table 1. Effect of substitutions of QacR residues E90 and E120 on drug-binding affinity (K d ) in vitro.
Table 2. Effect of substitutions of QacR residues E90 and E120 on induction in vivo.
Figure 2. Multidrug binding by QacR(E90Q). A - E) Superimpositions of the structures of the multidrug-binding pockets of wild type (wt) QacR- QacR-drug (light blue) and the corresponding QacR(E90Q)-QacR-drug (yellow) complexes

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