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Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity

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Academic year: 2017

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Table  1.  Hepatocyte  toxicity  induced  by  sumatriptan  and  protective  effect  of  antioxidants, mitochondrial  ATP  generators,  radical  scavengers,  lysosomal  membrane  stabilizers,  MPT  pore  sealing agents and CYP450 inhibitors
Figure  1.  Cell  cytotoxicity  induction  with  sumatriptan  (5  mM)  after  3  days  incubation  by  phenobarbital  and  the  effect  of  enzyme inhibition by 4- MP (500 µM) and cimetidine (2 mM)  Data  are  shown  as  mean±S.E
Table  2.  MMP  changes  induced  by  sumatriptan  in  rat  liver  hepatocytes  and  protective  effect  of  antioxidants  radical  scavengers,  lysosomal membrane stabilizers, mitochondrial ATP generators, MPT pore sealing agents and CYP450 inhibitors
Table  3.  Lysosomal  membrane  damage  induced  by  sumatriptan  in  rat  liver  hepatocytes  and  protective  effect  of  antioxidants,  radical  scavengers, lysosomal membrane stabilizers, mitochondrial ATP generators, MPT pore sealing agents and CYP450
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