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Transcriptional dysregulation in NIPBL and cohesin mutant human cells.

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Figure 1. Classifications of the 33 training samples by gene expression. (A) Unsupervised clustering of 17 healthy controls (blue dots) and 16 severe CdLS probands (red dots) by principle component analysis (PCA) of the 27,995 probe sets actively transcrib
Figure 2. Classifier genes are identified for CdLS. Clear progression of discriminant score (DS) from low to high is correlated with the phenotype from unaffected R mild R moderate R severely affected with CdLS
Figure 3. Cohesin binding analyzed in 15,162 unique tran- tran-scripts demonstrates preferential binding to TSSs and TTSs
Table 1. Cohesin associated to the +/2 1-kb vicinities of TSSs among three different groups of genes in control and CdLS LCLs.
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