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Quantitative dynamic modelling of the gene regulatory network controlling adipogenesis.

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Academic year: 2017

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Figure 2. The gene regulatory network (GRN, a - Model 1 ) and the modified GRN ( b - Model 2 ) of adipogenesis
Figure 3. Simulated dynamic expression levels of the three key markers, human CEBPb ( a , b ), CEBPa ( e , f ), PPARc ( i , j ), and mouse CEBPb ( c , d ), CEBPa ( g , h ), and PPARc ( k , l ), without ( Model 1 ) or with ( Model 2 ) additional feedbacks
Figure 5. Steady-state gene expressions in human and mouse adipocyte differentiation. The bistable states of CEBPa ( a , b ) and PPARc ( c , d ) due to elevation of CEBPb transcription rate, bistability of CEBPb ( e , f ) and PPARc ( g , h ) due to CEBPa e
Figure 6. Combined weighted-expression levels of TFs target- target-ing the three key markers, i.e
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