ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

Together with our previous study that activation of P2Y2 receptor by ATP promotes cell invasion and metastasis of prostate cancer cells, this study strongly indicates that P2Y2

We hypothesized that (i) anxiogenic-like pilocarpine effects seems to occur under non-toxic conditions since it does not induce electrographic seizures [ 6 , 7 ], hippocampal

multiple conformational states that couple differ- entially to specific effectors.The structural require- ments of the receptor for activation of G proteins, receptor and

Clearly ROR2-myc WT co-localisation with Rab5A was increased after 5 min but not after 30 min (Fig. 5A, upper and middle panels, respectively) of Wnt5a stimulation. These findings

Our previous results with Transient Receptor Potential Vanilloid 1 (TRPV1) capsaicin receptor deficient mice revealed that the activation of this ion channel by bradykinin,

subcircuits in EARM v1.0 comprise (i) a lumped-parameter representation of receptor binding by TNF or TRAIL and the subsequent activation of pro-C8 by receptor-bound

FRET changes induced by mAChR orthosteric and allosteric agonists in HEK293-M 1 -cam5 cells.. adrenoceptor have provided evidence for conformational and kinetic differences

( B , Bottom ) HEK293 cells stably expressing the human sst 5 receptors were either not exposed or exposed for 5 min to SS-14, octreotide, pasireotide or somatoprim in