Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.

In addition, decreased expression of Beclin 1 was inversely correlated with altered expression of Bcl-xL in ovarian carcinoma cohort, and combined analysis further showed that the

In order to validate the importance of the methylation profile in the regulation of gene expression, the transcription of tumor suppressor genes was performed in two

Furthermore, as revealed by qualitative analysis, the correlation between the methylation status of the MGMT promoter and the relative MGMT expression level (either positive

A network of core transcription factors (TFs) including OCT4, NANOG, KLF4, LIN28 and SOX2 promote the undifferentiated state of both hESC and human embryonal carcinoma cells (hEC)

to investigate the methylation status of P16INK4A in the full spectrum of cervical lesions as well as in normal epithelia and evaluate a possible association of this epigenetic

In our experiments, the G9 promoter fused to the reporter gene uidA showed maximal expression at stage 10 in transgenic tobacco (Figure 4), coinciding with the transcriptional

To gain an insight into the contribution of gene promoter methylation toward aberrant expression of RASSF3, we studied RASSF3 methylation status and its expression level in normal

In addition, SNPs in the IL18R1 promoter were associated with genotype-specific methylation status and genotype-specific IL18R1 expression, which together suggest that increased