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Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.

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Academic year: 2017

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Figure 2. MLK3 inhibition decreases transwell migration of breast cancer cells. (A) MDA MB-231 or (B) eGFP8.4 migrated toward 10% FBS in presence of 200 nM URMC099 or vehicle during 24 hours
Figure 4. Total number of brain metastases is not reduced in mice treated with URMC099

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