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Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.

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Academic year: 2017

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Figure 4. Nmnat2 siRNA triggers Wallerian-like degeneration of SCG neurites. (A) Representative fluorescent images of the distal ends of (DsRed2-labeled) neurites of wild-type (BL/6) or Wld S SCG neurons 24 and 72 h after injection with non-targeting siRNA
Figure 5. Neurite degeneration following si Nmnat2 injection precedes loss of neuronal viability
Figure 7. Endogenous Nmnat2 is present in SCG neurites and undergoes rapid turnover after transection
Figure 8. Exogenous Nmnat2 protects transected neurites for prolonged periods only when highly overexpressed

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