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Antipyretic therapy in critically ill patients with established sepsis: a trial sequential analysis.

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Fig 1. Flowchart of study selection. The initial search identified 402 citations after exclusion of duplicates.
Table 1. Characteristics of included RCT studies.
Fig. 5 shows the subgroup analysis by restricting to patients with septic shock. Three trials ful- ful-filled this criterion and the result showed there was no beneficial effect of antipyretic therapy on reducing mortality rate (OR: 1.11, 95% CI: 0.39–3.13
Fig 3. Meta-analysis with repeated non-superiority, non-inferiority and two-sided significance testing boundaries
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