Anticancer Effects of 1,3-Dihydroxy-2-Methylanthraquinone and the Ethyl Acetate Fraction of Hedyotis Diffusa Willd against HepG2 Carcinoma Cells Mediated via Apoptosis.

Objective: In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to

To investigate whether a mitochondrial pathway is involved in rhein-induced apoptosis of SGC-7901 cells, we used Western blot to detect the expression of cytochrome c and Apaf-1

induces ultrastructural signs of both apoptosis and au- tophagy in neonatal RGCs, 2) neonatal RGC death induced by axotomy partially depends on activation of caspase-9, -3

Chlorella vulgaris at 2 mg/ml (optimal dose) induced higher expressions of P53 (a), Bax (c) (proapoptotic) and caspase-3 (d) proteins in HepG2 cells compared to the control cells

lapachone and its derivatives (1, 3 and 4) induced apoptosis (mitochondrial pathway) in HL- 60 cells, based upon morphological and flow cytometric analysis, and interference on HL-60

Importantly, the activation of the caspase cascade and caspase-8-mediated RIP1 cleavage in TNF a -stimulated TAK1 deficient cells is not sufficient to prevent RIP1-dependent

Though the main apoptosis pathway in both cell lines was found to be through caspase-8 activation, caspase-9 was also activated in MDA-MB-231 cells but suppressed in MCF-7 cells..

BP-C1 , is significantly reduced cell viability of human breast cancer cells through induction of apoptosis via activation of caspase 8 and caspase 9, increasing the expression