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Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

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Academic year: 2017

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Figure 1. Nampt inhibition with FK866 prevents T lymphocyte proliferation and selectively kills activated T cells
Figure 3. PARP inhibitors and sirtinol attenuate FK866-induced T cell demise. A, PBLs were cultured for 24 h with or without PHA.
Figure 5. Nam and Na prevent NAD + shortage and cell death induced by FK866 in human T lymphocytes
Figure 9. A putative model of Nampt’s role in activated T lymphocytes. Nampt activity is responsible for providing sufficient NAD + supplies during T cell activation

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