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Design, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity.

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Academic year: 2017

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Figure 4. Cumulative concentration-response curves for Ca 2+ in the presence of the vehicle and increasing concentrations of 16c (0.1–10 mM) in isolated endothelium-intact aortic rings (n = 5)
Figure 6. Effect of 16c on L-type Ca 2+ channel currents in vascular smooth muscle cells (A) and on I–V relation of Ba 2+ currents in vascular smooth muscle cells (B)

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