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Kineret®/IL-1ra blocks the IL-1/IL-8 inflammatory cascade during recombinant Panton Valentine Leukocidin-triggered pneumonia but not during S. aureus infection.

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Academic year: 2017

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Figure 2. IL-8 produced in response to S. aureus supernatant by a co-culture of macrophages and lung epithelial cells is dependent on IL-1 signaling, while IL-8 produced by neutrophils is independent of IL-1
Figure 4. Sequential intratracheal instillation of HKS and rPVL triggers IL-1b and IL-8 release and reproduces some key aspects of S.
Figure 6. Kineret/IL-1Ra does not reduce IL-8 levels during PVL + S. aureus -mediated pneumonia but increases lung bacterial load.

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