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Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.

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Figure 1. Identification of residues in the NP of the pandemic 1918 influenza A virus responsible for resistance to murine Mx1
Figure 2. Identification of residues in the NP of the pandemic 2009 influenza A virus responsible for resistance to murine Mx1
Figure 5. Mx resistance is accompanied by impaired viral growth in cell culture. (A–B) H5N1 polymerase activity in HEK293T cells after co- co-transfection of the indicated expression plasmids coding for NP (100 ng) and MxA (200 ng) (A) or porcine Mx1 (poMx
Figure 6. Mx resistance-enhancing mutations in NP increase the virulence of the H5N1 isolate KAN-1 in Mx1-positive mice
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