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TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.

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Academic year: 2017

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Figure 1. TWIST1 expression in tumor samples. A. Assessment of TWIST1 expression by quantitative RT-PCR in EGFR mutated (M) and wild type (WT) tumors assessed by quantitative RT-PCR
Table 1. Expression of TWIST1, mesenchymal (CDH2, VIM, SNAI1, ZEB1) and epithelial (CDH1, JUP) markers in lung adenocarcinoma cell lines.
Figure 4. EGF induces EMT only in cells with EGFR mutation and TWIST1 expression. EGFR mutated human lung cancer cell lines (H1975, H1650, HCC827) were treated with EGF
Figure 7. EGF-induced EMT associates with a gain in motility. Human lung cell lines harboring different TWIST1 and EGFR status were treated with EGF and tested for their motility in scratch (panel A) and transwell migration (panel B) assays

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