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Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.

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Figure 1. Expression of cadherin-11 in developing murine retina. (A) Cadherin-11 was expressed in the differentiating layer at (embryonic day) ED18.5, by retinoblasts at (post natal day) PND3 and again in a differentiating layer at PND6
Figure 4. Gradual loss of cadherin-11 expression in TAg-RB tumors. (A) At PND9 TAg-RB mice displayed single TAg-positive cells (green) also positive for cadherin-11 (red)
Figure 5. Cdh11 genomic copy number correlates with number of TAg-positive cells (origin of tumors in TAg-RB mice) at PND8
Figure 6. At PND28, fewer multifocal tumors developed when Cdh11 alleles were lost. (A) A distinct Cdh11 loss phenotype was observed from representative sections of TAg and H&E stains
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