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Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways.

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Academic year: 2017

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Figure 1. Plot of significance versus fold change of all significant genes. Plot of significance (absolute value of d, |d|) versus log2 fold change, for all 3,855 genes called significant at q , 0.1
Table 1. Aging-related genes upregulated or downregulated by CR, q,0.01.
Figure 4 displays the frequencies (at both permissive and restrictive cutoffs) of each of four classes of genes: increased by CR and more highly expressed (UP) in females, increased by CR and UP in males, decreased by CR and displaying lower expression (DO
Figure 4. CR feminizes overall gene expression. Fractional distributions of all genes changed by CR and which display sexually dimorphic expression in the data of Yang et al

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