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cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

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Academic year: 2017

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Figure 4. Requirement of cIAP1/2 for RIP1–4-mediated NF- k B activation. (A) NF-kB luciferase assays were performed on lysates from HEK293T cells transfected with a plasmid encoding the indicated RIP kinase or TAK1
Figure 5. Lysine residues K51 and K145 of RIP4 are critical for cIAP1-mediated ubiquitination and NF- k B activation

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