Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition.

With the elements of K determined for mESC proliferation and transition between patterns of allelic Nanog expression and the single-cell gene expression model in place, we proceeded

To investigate this, we used a cell culture model in which MIWI2 expression is knocked down by shRNA, and a mouse model in which the animals lack a functional MIWI2 gene to test

Although transduction of each of the Hox derivatives slightly increased mRNA for Geminin (Fig. 4B), protein expression levels of Geminin were reduced by the transduction of

(A–J) Development of the embryonic liver was monitored by the expression pattern of the lfabp gene in wild-type embryos and hif2-alpha ATG-MO-injected embryos at 1–5 dpf by

In addition to the anticipated alterations in myelin gene expression, we identified novel gene targets regulated by the p38 pathway, including transcripts encoding proteins that

In our study, anandamide inhibited the proliferation of gastric cancer cells and mediated G2/M cell cycle arrest by altering the expression of the cell cycle regulators. This

To assess whether gene expression by the reprogrammed cell is stable (self sustaining) or requires the continuous supply of factors provided by the mouse ES cell, we generated

In addition, at the level of individual embryos, expression of end-1 and end-3, and another very early E-specific zygotic gene, sdz-23, exhibit stochastic and discordant defects in P