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Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells.

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Academic year: 2017

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Figure 1. Schematic of materials synthesis and characterization. (A) Synthesis of PUR networks from an LDI quasi-prepolymer (red) and a poly(e-caprolactone-co-glycolide) triol with molecular weight M n = 3w, where w is the equivalent weight (g eq 21 )
Figure 3. Expression of Gli2 and by MDA-MB-231 and RWGT2 cells increases with increasing substrate modulus
Figure 4. Mechanotransduction signals are regulated by values of the substrate modulus in the MPa range
Figure 5. TGF-ß mediates the response of MDA-MB-231 cells to substrate rigidity. (A) PTHrP gene expression increases significantly for MDA-MB-231 cells transfected with the plasmid control (MDA-pc), while MDA-MB-231 cells transfected to express a dominant
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