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Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1

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Academic year: 2017

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Figure 1 Establishment of the GSIS experimental system in MIN6 cells. (A) MIN6 and MIN7 cells were stimulated with the indicated glucose concentrations for 1 h and insulin secretion was determined as the difference between the medium insulin concentration
Figure 2 Reversible inhibition of GSIS by isoflurane and sevoflurane. (A) and (B) MIN6 cells were stimulated with the indicated glucose concentrations for 1 h, with or without the indicated dose of isoflurane (iso) (A) or sevoflurane (sev) (B), prior to ca
Figure 3 The effect of volatile anesthetics on molecular aspects of GSIS in MIN6 cells
Figure 4 The effect of volatile anesthetics on intracellular signaling processes involved in GSIS
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