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A synthetic peptide selectively kills only virulent Paracoccidioides brasiliensis yeasts

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Academic year: 2017

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Fig. 1. Pb18 isolates displayed clear differences in degree of virulence. (A) Survival curves of B10.A mice inoculated i.t
Fig. 3. P04 as a biomarker of virulence. Cell binding assays were performed with p04 and control phage (fd-tet phage, no insert)
Fig. 4. Pep04 binding to virulent Pb18 isolate. (A) The majority of attenuated Pb18 cells showed no labeling with pep04 coupled to 6-FAM by fluorescence microscopy
Fig. 5. The in vitro antifungal activity of selected peptides. (A) Pep04 (P < 0.01), pep05 (P < 0.01) and pep06 (P < 0.05) peptides incubated with yeasts of virulent Pb18
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