• Nenhum resultado encontrado

Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection.

N/A
N/A
Protected

Academic year: 2017

Share "Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection."

Copied!
14
0
0

Texto

Loading

Imagem

Figure 1. Characterization of peripheral T FH cells. (A) Left: Representative flow cytometry plots from HIV-uninfected PBMC showing the gating scheme for isolating T cell subsets for the T cell/B cell coculture assay
Figure 2. Progressive loss of pT FH cells in HIV infection. (A) Pooled data showing the frequency (%) of CXCR5 high , CXCR5 high CCR6 high and CXCR5 high CCR6 high PD-1 high populations in total CD4 cells from PBMC from HIV uninfected (open circles; n = 13
Figure 3. Impaired B cell help by pT FH cells in HIV infection. (A) CCR7 high CXCR5 low and CCR7 high CXCR5 high CCR6 high CM CD4 T cells isolated from PBMCs were cultured with autologous naı¨ve B cells (CD19 high CD27 low IgD 2 ) in the presence of SEB fo
Figure 5. Relationship between pT FH cells and neutralization activity. (A) Correlative analysis showing the frequency (%) of CXCR5 high , CXCR5 high CCR6 high and CXCR5 high CCR6 high PD-1 high populations in total CD4 cells from HIV-infected (treatment n

Referências

Documentos relacionados

By analyzing the beneit according to the degree of hearing loss, it was found that among the elderly with symmetrical hearing loss, two with mild sensorineural hearing

4 – Correlation among the relative frequency of Th17 cells and CD4+CD69+ T cells in cultures of PBMC of patients with I-SLE without stimulation (A), culture stimulated with HEp-2

Results: We found ACS patients had a significantly lower frequency of circulating CD4 + LAP + Tregs, and the function of these cells was reduced compared to controls.. The expression

T cells with partially opposing effect on neointima formation and that the lack of effect observed in MHC class II deficient mice is explained by a loss of all of these cells.

Following co-culture, transduced cells were analyzed using CD45RO and CD62L, and similar to our observations with PBL, we observed a loss of CD62L expression (presumptively by

We aimed to study the capacity of memory circulating Tfh (cTfh) cells to promote B cell help in acute HIV infection, and found the interaction to be dysfunc- tional in the later

There was also a greater induction of IFN- c + cells in the B cell gate than in the CD4+ or CD8+ T cell gate (Figure 5D–E) and the percentage of IFN- c + B cells in total

Whereas the frequencies of CD4 + and CD8 + cells did not differ following chronic alcohol ingestion and sepsis, the frequency of NK cells was lower in both the spleen and bone marrow