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Elucidation of the binding mechanism of coumarin derivatives with human serum albumin.

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Academic year: 2017

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Figure 1. Chemical structures of 7-hydroxy-4-methyl coumarin derivatives with their IUPAC names
Figure 4. Circular dichroism of the free HSA and HSA+coumarin derivatives complexes. (A) the free HSA and HSA+CD enamide complexes in aqueous solution with a HSA concentration of 0.001 mM and CD enamide concentrations were 0.001, 0.003 and 0.005 mM
Figure 6. CD enamide docked in the binding pocket of HSA using Autodock4.2. Different view of HSA and CD enamide docked conformation
Figure 8. CDM enamide docked in the binding pocket of HSA using Autodock4.2. Different view of HSA and CDM enamide docked conformation
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