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Model-based traction force microscopy reveals differential tension in cellular actin bundles.

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Academic year: 2017

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Fig 1. Actin cytoskeleton and traction force microscopy. (A) Schematics of a cell cultured on a soft elastic substrate with embedded fluorescent marker beads
Fig 2. Computational workflow of MBTFM. (A) Actin and paxillin images are segmented and converted into a whole cell model, with an individual tension value assigned to each stress fiber and one global tension value assigned to the actin networks of the cel
Fig 3. Orientation analysis of focal adhesions, stress fibers, and local displacements for U2OS-cells
Fig 4. Robustness of MBTFM and comparison with FTTC. (A) Realistic traction patterns are generated by calculating the direct problem for a known test tension distribution
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