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Formal modeling and analysis of ER-α associated Biological Regulatory Network in breast cancer

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Academic year: 2017

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Figure 1 IGF-1R and EGFR signaling pathway. (A) Ligand activated Insulin growth factor receptor-1 (IGF-1R) signaling starts from the membrane to induce the insulin receptor-1 signaling
Figure 2 Work Flow Diagram presenting the structure and organization of the study. (A) Inference of biological observations of signaling pathways from literature survey (B) construction of interactions of proteins in the metastasis of Breast cancer (C) app
Figure 3 Activation and inhibition of x. Discretization of the sigmoid curve to represent activation (+) of gene x at threshold level θ and inhibition (−) at level θ + 1.
Figure 4 Representation of association reactions between entities. (i) Activation: entity A tends to ac- ac-tivate another entity B (ii) Inhibition: entity A stops the activity of entity B
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