• Nenhum resultado encontrado

IL-6 amplifies TLR mediated cytokine and chemokine production: implications for the pathogenesis of rheumatic inflammatory diseases.

N/A
N/A
Protected

Academic year: 2017

Share "IL-6 amplifies TLR mediated cytokine and chemokine production: implications for the pathogenesis of rheumatic inflammatory diseases."

Copied!
10
0
0

Texto

Imagem

Figure 1. TNF-a, CCL2 and CXCL8 production in human PBMCs exposed to IL-6. Human PBMCs were exposed to IL-6 (10 ng/ml) in combination with sIL-6R (125 ng/ml) (IL-6/sIL-6R) for 18 hours
Figure 4. Increased p65 NF-kB activation in response to inflammatory stimuli in human PBMCs pre-exposed to IL-6/IL-6R
Figure 6. Exposure to IL-6 enhances cytokine and chemokine production in SFMC. SFMC were left to adhere on plastic for 3 hours in DMEM supplemented with 10% fetal calf serum (FCS)
Figure 8. Western blots showing the expression of phospho–STAT3 (Tyr 705 ), phospho–NF-kB (Ser 536 ) in total lysates of RA synoviocytes pretreated as in Figure 7B for 1 hour and then stimulated with IL-1b (1 ng/ml) or LPS (10 ng/ml) for 90 minutes.

Referências

Documentos relacionados

Para o produtor, os visitantes ou são “sophisticated drinker”, que anseiam por novas informações e a maneira como elas podem ser obtidas, que correspondem a uma baixa

Activated microglial cells are efficient in the production of pro-inflammatory cytokines (M1-like phenotype), including IL-1ᵝ, TNF-α, IL-6 and IL-8 (Verkhratsky and Butt

The objective of this study was to investigate the anti-inflammatory potential of Otosporin® by histological analysis and immunoexpression of pro-inflammatory cytokines TNF- α ,

Effect of IL-10 + adiponectin treatment for 24 h on IL-6 level in the culture medium and on protein expression of IL-6R, TLR-2, and TLR-4 in 3T3-L1 adipocyte treated with LPS.

Methods and Findings: We measured plasma levels of soluble UA and inflammatory cytokines and chemokines (IL-6, IL-10, sTNFRII, MCP-1, IL-8, TNF a , IP-10, IFN c , GM-CSF, IL-1 b )

A hipótese que norteou a presente dissertação foi ‘‘A Qualidade de Vida Relacionada à Saúde em paciente com artrite reumatoide é associada negativamente à presença de

We have previously observed this commonality in the presence of inflammatory cytokines [interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoat- tractant protein-1 (MCP-1)]

PAR-1 activation triggers the production of several inflammatory mediators, including IL-6, IL-8 and MCP-1, and induces cell proliferation through the coupling of receptor activation