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Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection.

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Figure 1. Chemical structure of CRX-601.
Figure 5. IL-17A neutralization reduces augmented neutrophil response. Mice vaccinated intranasally with split influenza virus antigen (A/
Figure 8. Heterogeneous expression of CCR6 on vaccine primed Th17 cells. 5 days post influenza challenge, lung CD4 + T cells from vaccinated mice were examined for antigen-specific IL-17A or IFNc expression (A), then gated subsets were examined for transcr
Figure 9. Influenza virus-primed mice maintain a Th1 profile following subsequent intranasal vaccination

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