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Intronic L1 retrotransposons and nested genes cause transcriptional interference by inducing intron retention, exonization and cryptic polyadenylation.

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Academic year: 2017

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Figure 1. Snapshot of L1- and nested gene-induced TI from UCSC Genome Browser [39]. Schematic representation of (A) intron retention in TRPC4AP (ESTs: DA794245, DB292589) upstream to full-length L1 PA5 element, (B) forced exonization and cryptic polyadenyl
Figure 4. L1-induced transcription decreases SV40 transcription and causes intron retention in ABCA minigene
Figure 5. TI effects of L1 SP and ASP, cryptic splice site and polyA signals in ABCA minigene
Figure 6. L1-induced transcription interferes with exon skipping and intron retention in NCAM minigene
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