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ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

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Academic year: 2017

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Figure 1. The muscle weakness phenotype of the Mariusz mutant. (A) The original pedigree in which the Mariusz mutant was identified
Figure 2. The digit fusion phenotype of the Mariusz mutant. (A) Examples of different fusion phenotypes observed - four toes (#1), four toes with two toes fused (#2), four toes with skewed digit (#3), mixture of two digit phenotypes in a single mouse (#4)
Figure 3. Genetic linkage analysis and positional cloning of the Mz mutation. (A) Genotypes of seven informative recombinants exhibiting the Mariusz phenotype
Figure 5. Muscle force measurements in Mariusz mice. (A) Morphometric measurement of cross-sectional area of Mariusz muscles in histological sections normalized to the area of the muscle in wild type controls (n = 3 mice each genotype at 5 weeks of age; n

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