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Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication.

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Academic year: 2017

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Figure 2. Effect of Bispidine derivatives on JEV infection. (A) Viral titers were determined by plaque assay of N2A cell culture supernatants (22 h pi) infected with JEV and treated with 100 mM of derivatives of bispidine
Figure 3. Synthesis of amino acid conjugates of bispidine. (A) Structure of bispidine conjugated with tryptophan (Bisp-W), lecine+phenylalanine (Bisp-LF) and lysine (Bisp-K)
Figure S1 IC50 value for Bisp-LF. IC50 value was estimated by measuring viral titers in cell culture supernatants (22 h p.i.) infected with JEV and treated with the indicated concentration of Bisp-LF

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