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Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells.

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Academic year: 2017

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Figure 1. Transgene-free method for isolating iPGCs from embryoid bodies. A: V6.5 embryoid bodies in hanging drops at days 4, 5, and 6 of differentiation
Figure 2. iPGCs have characteristics of pre-gonadal, pre-reprogrammed in vivo PGCs. A: Immunofluorescence of pre-gonadal e10.5 PGCs stained for Oct4 (red) and Mvh (green)
Figure 3. Developmental staging of pre-gonadal iPGCs at single cell resolution. A: Bright field image of representative e9.5 Oct4-gfp embryo
Figure 4. Transcriptional profiling demonstrates a PGC program and identifies novel markers for bona fide iPGCs from ESCs

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