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miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer.

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Academic year: 2017

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Figure 2. ADIPOR1 negatively regulates the EMT. (A) qRT-PCR analysis of MCF10A cells, 48 hours post transfection with either non-targeting control (NTC) or ADIPOR1 siRNA
Figure 3. ADIPOR1 wildtype and siRNA mutant plasmids rescue miR-221/222 mimic and ADIPOR1 siRNA-induced EMT,  respec-tively
Figure 4. ADIPOR1 protects against the EMT by negatively regulating the NF- k B, IL6, and JAK2/STAT3 signaling axis
Figure 5. ADIPOR1 overexpression attenuates the EMT and invasion. (A) Western Blot analysis of anti-Flag and canonical NF-kB markers in MDA-MB-231 cells 2 days after passaging cells

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