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An Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome Adaptors.

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Academic year: 2017

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Fig 2. Dose-dependent degradation of the target protein. (a) Experimental design. HEK293 cells co-expressing the adaptor (UbL-mCherry-FRB-MBP) and target (FKBP-GFP-tail) were seeded 24 hours in advance
Fig 3. Rapalog-induced target degradation. (a) Experimental design. HEK293 cells co-expressing the adaptor (UbL-mCherry-FRB-MBP) and substrate (FKBP-GFP-tail) were seeded 24 hours prior to drug treatment
Fig 5. Model for Adaptor-CID-mediated degradation of target proteins. Schematic representation of adaptor-mediated degradation of a target protein by the proteasome

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