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The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse.

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Academic year: 2017

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Figure 1. The HIV VS has a regulated secretion phenotype. A) The MTOC aligns proximal to the VS in the HIV-1 infected T cell
Figure 4. HIV-1 Env colocalizes with SL-associated proteins following endocytosis from the plasma membrane
Figure 5. CHS CD4 + T cells are less able to support HIV-1 replication in culture. A) CHS CD4 + T cells (black bars) and cells from normal WT donors (white bars) were infected with HIV-1 and supernatants were taken at various days post-infection and virus
Figure 6. CHS cells support HIV-1 infection and Gag budding over a single- round of replication but transmit virus less efficiently by cell-to-cell spread

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