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Antinociceptive effect of novel pyrazolines in mice

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Academic year: 2019

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Table 1. Effects of pyrazoles 1, 2 and 3 and morphine on mouse tail withdrawal latency (in seconds) at 15, 30 and 60 min after injection.
Table 1 shows the effect of Pz 1 and its corresponding 1-substituted methyl (Pz 2) and phenyl (Pz 3) analogues (1.5 mmol/kg) on the latency of tail withdrawal from hot water
Figure 2. Effects of Pz 2 administration on the latency for the first fall (A) and on the number of falls (B) from the rotarod
Figure 4. Effect of naloxone on the antinociception (A) and immobility (B) induced by Pz 2 and Pz 3

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