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Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.

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Academic year: 2017

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Figure 1. Pharmacologic inhibition of BMP signaling reduces osteogenic activity in the aortas of MGP-deficient mice
Figure 2. Vascular calcification associated with MGP deficiency is dependent on bone morphogenetic protein signaling
Figure 3. Inhibition of BMP signaling improves survival of MGP -/- mice. MGP -/- mice were treated once daily with LDN-193189 (LDN) or vehicle starting at day 1 of life
Figure 4. Vascular calcification associated with MGP deficiency occurs in the absence of vascular inflammation
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