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Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation.

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Academic year: 2017

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Figure 1. The (GCP4-c-tubulin) 2 tetramer. (a) The starting structure of the tetramer
Figure 1b shows the variation of RMSD of the system and its components as a function of time, calculated from a superposition of atomic coordinates for each frame of the trajectory with respect to the first of the saved frames (the first frame represents t
Figure 5. Superimposition of the 10 top positions of the best fragments. a. Cartoon representation of the binding site
Figure 4 shows the distribution of physicochemical properties such as molecular weight (MW), log P, log S, heavy atoms count
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