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TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment.

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Academic year: 2017

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Figure 1. TGF-b-neutralizing antibody1D11 suppresses TGF-b signaling in AML cells. (A) Percentage of MV4;11, U937 and THP-1 cells showing annexin V positivity after 72 hours of treatment with or without rhTGF-b1 (2 ng/ml) and the indicated concentrations o
Figure 4. Plerixafor and 1D11 inhibit CXCL12-induced migra- migra-tion. Chemotaxis assay of MV4;11 cells treated with TGF-b1 (2 ng/ml), 1D11 (10 mM), and/or plerixafor (1 mM) for 18 hours
Figure 6. Simultaneous blockade of TGF-b and CXCL12/CXCR4 signaling may enhance the efficacy of chemotherapy against AML cells in the hypoxic BM microenvironment

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