Evolutionary constraint helps unmask a splicing regulatory region in BRCA1 exon 11.

Endoplasmic reticulum stress- induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Two regulatory

Comparison with gene expression-based metrics To determine whether a similar accuracy could have been obtained using expression data alone (i.e., without adding constraints based on

We present here a study of AhR gene polymorphism in normal and cancer human tissues affecting pre-mRNA splicing in the AhR gene-coding transactivation domain region (exon 10,

Several regulatory sequences have been identified in the CR of the vertebrate’s species and have been shown that this region contains H-strand origin, H- strand

Several regulatory sequences have been identified in the CR of the vertebrate species and shown that this region contains H-strand origin, H-strand promoter,

Key words: antisense oligonucleotide-mediated splicing redirection mutations, exon skipping, mismatch repair, mutation-targeted therapies, translational readthrough..

However, the 39 nt spliced leader (mini-exon, the 5’ exon sequence transferred to trypanosome mRNAs by the mechanism of trans splicing) shows a variable pattern of high and

However, the 39 nt spliced leader (mini-exon, the 5’ exon sequence transferred to trypanosome mRNAs by the mechanism of trans splicing) shows a variable pattern of high and