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Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients.

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Academic year: 2017

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Table 1. Baseline clinical characteristics of patients included in the study.
Fig 1. Increased frequency of G-MDSC in CML patients. A. Circulating G-MDSC were quantified and expressed as percentage of CD11b+CD33+CD15+
Fig 2. CML-MSC-educated G-MDSC are immunosuppressive. A. HD- and CML-MSC generate similar amount of G-MDSC
Fig 3. Expression of immunomodulatory factors by CML-MSC. Compared to HD-MSC, CML-MSC showedsignificant up-regulation of IL6, COX2and TGFβ at Time 0 (A) and overexpressed IL6, TGFβ and IL10 after 48 h of co-culture with PBMC (B)
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