Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

Most Caucasian patients with hereditary hemochromatosis (HH) are homozygous for HLA-A3 and for the C282Y mutation of the HFE gene, while a minority are compound

Hereditary hemochromatosis is a disorder of iron metabolism charac- terized by increased iron intake and progressive storage and is related to mutations in the HFE gene..

In view of the severity of liver disease in HBV patients, and the viral genetic characteristics as determinants of liver disease progression, the present study aimed to develop a

The fact that Nrf2 -/- mice fed iron-rich diet develop marked liver injury despite a similar hepatic iron loading to wild-type animals is of great relevance

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Trata-se, portanto, de uma referência importante para o conhecimento do quotidiano de Alte em finais do século XIX e princípios do século XX que incluímos uma vez que, apesar

Com isso, houve a possibilidade da organização de um plano de gestão municipal que levou em con- sideração aspectos sociais e ambientais da questão dos resíduos sólidos

Knowing that fatty liver disease is an early event in the development of insulin resistance that predicts the presence and the progression of the metabolic syndrome [12], the