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Crosstalk between NF-kB and PI3K-Akt-mTOR signalling in thyroid cancer: the pursuit of novel therapeutic options

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Academic year: 2021

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Figure  1.1-  Hallmarks  of  cancer.  This  figure  encompasses  the  classic  hallmarks  of  cancer  along  with  the  two  new  emerging hallmarks and enabling characteristics
Figure  1.2-  Classic  MAPK  signalling  pathway.  MAPK  pathway  is  a  signalling  pathway  essential  for  normal  cell  maintenance  and  survival  and  its  abnormal  activity  is  frequently  involved  in  cancer
Figure  1.3-  PI3K/Akt/mTOR  signalling  pathway.  PI3K/Akt/mTOR  pathway  is  essential  for  normal  cell  function  and  survival and its dysregulation is often seen in cancer
Figure  1.4-  Canonical  and  non-canonical  pathways  of  NF-κB.    NF-κB  transcription  factor  regulates  several  biological  aspects  such  as  inflammation  and  cell’s  growth  and  apoptosis,  which  are  essential  during  cancer’s  formation
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