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Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes.

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Academic year: 2017

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Table 1. A list of top 5 genes upregulated in astrocytes by MeHg (10 mM, 2 hr).
Figure 2. IL-6 upregulation by MeHg is mediated by P2Y 1 receptors followed by p38 activation
Figure 3. Exocytotic ATP release and Ca 2+ oscillation in astrocytes evoked by MeHg. (A) MeHg increased the extracellular ATP level of astrocytes
Figure 5. Neuro-protection by astrocyte-derived IL-6. (A) The experimental schedule. MeHg (1 or 3 mM) was treated to the astrocyte culture for 24 h and the ACM was transferred into the neuronal culture
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