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Sonic hedgehog carried by microparticles corrects angiotensin II-induced hypertension and endothelial dysfunction in mice.

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Academic year: 2017

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Figure 1.  Time course of changes on systolic blood pressure and heart rate.  Effects of either microparticles (MPs Shh+) or cyclopamine on systolic blood pressure (A)
Figure 2.    Concentration–response curves to acetylcholine (ACh) and nitric oxide and superoxide anion productions in aorta
Figure 3.  Vascular response of small mesenteric arteries to flow.  Flow-induced dilation obtained in small mesenteric arteries from mice receiving saline (control, CTL), microparticles alone (MPs Shh+), angiotensin II (ANG II), and the combination of ANG

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